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1- department of physical education and sports sciences central tehran branch, Islamic Azad University, Tehran, Iran
2- department of physical education and sports sciences central tehran branch, Islamic Azad University, Tehran, Iran ,amir.hajighasem01@gmail.com
3- department of physical education, Pardis Branch, Islamic Azad University, pardis, Iran
4- department of physical education and sports sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
2- department of physical education and sports sciences central tehran branch, Islamic Azad University, Tehran, Iran ,
3- department of physical education, Pardis Branch, Islamic Azad University, pardis, Iran
4- department of physical education and sports sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract: (27 Views)
Background and objectives: Non-alcoholic fatty liver disease (NAFLD), a highly prevalent and chronic liver disease, is characterized by a diverse range of conditions that span across a broad spectrum. Engaging in consistent physical activity has proven to be a successful method in effectively managing NAFLD, as it has demonstrated the ability to enhance crucial elements implicated in the development of the condition
Methods: Twenty-one male Wistar rats were divided into three groups: 1) NAFLD, 2) NAFLD + resistance training (RT), 3) NAFLD + RT + atorvastatin (ATO). The groups received high fat/fructose diet (HFFD) to induce NAFLD and it was confirmed through evaluation of histopathological analysis (H&E staining) and measurement of aminotransferase enzymes. ATO was administrated at the dose of 2 mg/kg/day. The interventions were done for eight weeks.
Results: Triglyceride (TG), Alanine transaminase (ALT), and aspartate transaminase (AST) were significantly reduced in the NAFLD + RT + ATO. Also, low-density lipoprotein (LDL) had lower level in NAFLD + RT in compared to NAFLD + RT + ATO. Alkaline phosphatase (ALP) was reduced in both NAFLD + RT and NAFLD + RT + ATO groups compared to NAFLD. There was no significant difference in weight between the groups except first, second, and forth week.
Conclusion: RT in combination with the administration of ATO can be deemed as an efficacious and supplementary strategy for the purpose of effectively controlling and addressing NAFLD.
Methods: Twenty-one male Wistar rats were divided into three groups: 1) NAFLD, 2) NAFLD + resistance training (RT), 3) NAFLD + RT + atorvastatin (ATO). The groups received high fat/fructose diet (HFFD) to induce NAFLD and it was confirmed through evaluation of histopathological analysis (H&E staining) and measurement of aminotransferase enzymes. ATO was administrated at the dose of 2 mg/kg/day. The interventions were done for eight weeks.
Results: Triglyceride (TG), Alanine transaminase (ALT), and aspartate transaminase (AST) were significantly reduced in the NAFLD + RT + ATO. Also, low-density lipoprotein (LDL) had lower level in NAFLD + RT in compared to NAFLD + RT + ATO. Alkaline phosphatase (ALP) was reduced in both NAFLD + RT and NAFLD + RT + ATO groups compared to NAFLD. There was no significant difference in weight between the groups except first, second, and forth week.
Conclusion: RT in combination with the administration of ATO can be deemed as an efficacious and supplementary strategy for the purpose of effectively controlling and addressing NAFLD.
Research Article: Research Article |
Subject:
Sport Physiology
Received: 2023/10/8 | Accepted: 2024/01/8
Received: 2023/10/8 | Accepted: 2024/01/8
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.