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Background: Pathological autopsy plays a crucial role in understanding mortality causes, especially in cases where diagnosis during life was incomplete or impossible. The collaboration between forensic experts and pathologists provides valuable insights into the cause and manner of death. Aim: The study aimed to determine the prevalence and pattern of lung, liver, and kidney histopathology, assess demographic associations, and investigate etiological factors contributing to these pathologies. Methods: A retrospective, non-interventional, record based cross sectional study was conducted for a period of five years from 1st January 2019 to 31st December 2023, analyzing 90 autopsy cases excluding decomposed bodies and cases primarily due to extensive trauma. Results: Lung pathology was observed in 61.1% of cases, predominantly showing congestion and inflammation. Liver diseases were found in 47.7% of cases, with steatosis and cirrhosis notable, especially among males. Kidney pathology was present in 50% of cases, with various changes noted. Demographic distribution indicated a higher prevalence among males, with sudden death, chronic alcohol abuse, and road traffic accidents being common causes. Conclusion: The study emphasizes the significant burden of lung, liver, and kidney pathology in autopsy cases, particularly among males, highlighting the importance of autopsy in understanding the underlying causes of death and guiding public health interventions and forensic investigations.