Showing 43 results for Training
Roohollah Mohammadi Mirzaei, Hamid Malekshahiniya, Halimeh Vahdatpoor,
Volume 19, Issue 2 (3-2025)
Abstract
The aim of this study is to investigate the effect of 6 weeks of intermittent exercise on the serum level of nitric oxide, insulin resistance and some lipid profiles in male diabetic rats. Materials and methods: In this experimental study, 60 anesthetized rats (200±20) were randomly divided into 6 groups of 10:1-control-healthy, 2-sham, 3-periodic, 4-periodic+saline, 5-diabetic and 6- Diabetes + interval training were divided. Diabetes was induced by intraperitoneal injection of nicotinamide-streptozotocin. The subjects trained on the treadmill for 6 weeks, 5 sessions a week. 48 hours after the last training session, slaughter was performed and then glucose, insulin, nitric oxide, LDL, HDL, TG and cholesterol levels were measured. One-way variance test and Tukey's post hoc test were used for data analysis(p<0.05). Results: Induction of diabetes increased glucose and insulin resistance and decreased insulin and nitric oxide in the diabetic group compared to the control group. After 6 weeks of intermittent training in the diabetes group + intermittent training, the amount of glucose and insulin resistance decreased compared to the diabetes group, but the nitric oxide level increased compared to the diabetes group. But it had no effect on insulin levels. Also, 6 weeks of intermittent training had no significant effect on the amount of lipid factors in different groups(p<0.05). Conclusion: According to the results of the present study, it seems that interval training can create a protective effect against vascular diseases in diabetic patients by reducing insulin resistance and increasing nitric oxide, and as a result, improving vascular function.
Seyed Abdollah Hashemvarzi, Behrooz Mohammadnezhad,
Volume 19, Issue 2 (3-2025)
Abstract
Background and objectives: Inflammation plays a major role in the development and progression of diabetes. Vitamin D deficiency and physical inactivity can also increase the risk of developing type 2 diabetes. Combined therapeutic strategies are promising approaches for the treatment and prevention of diabetes. The aim of this study was to investigate effects of resistance training, vitamin D3 supplementation and adipose-derived mesenchymal stem cell (MSC) transplantation on tumor necrosis factor-beta level in the cerebral cortex of diabetic rats.
Methods: Eighty male Wistar rats (weighing 290±19 g) were randomly divided in to 10 groups: healthy control, sham, diabetes, training, vitamin D, MSC, training+vitamin D, MSC+training, MSC+vitamin D and training+MSC+vitamin D. Training groups were subjected to a resistance training program on ladder. MSC groups received 1.5 × 106 MSCs and vitamin D supplementation groups received 1 microgram/kilogram vitamin D3 eight times. Cortical TNF-β level and fasting serum glucose levels were measured.
Results: After 6 weeks, the combination of resistance training with vitamin D3 supplementation and MSC transplantation (P=0.018) as well as the combination of resistance training with MSCs (P=0.024) significantly reduced diabetes-induced elevation of TNF-β level.
Conclusion: Resistance training with appropriate intensity, duration and recovery between exercise sessions, combined with MSC transplantation and vitamin D3 supplementation has profound anti-inflammatory effects on the cerebral cortex tissue of diabetic rats. This type of intervention, especially the transplantation of MSCs, may be a promising protective strategy against some complications of diabetes.
Raouf Moradian, Amir Haji Ghasem, Saleh Rahmati, Lida Moradi,
Volume 19, Issue 2 (3-2025)
Abstract
Background and objectives: Non-alcoholic fatty liver disease (NAFLD), a highly prevalent and chronic liver disease, is characterized by a diverse range of conditions that span across a broad spectrum. Engaging in consistent physical activity has proven to be a successful method in effectively managing NAFLD, as it has demonstrated the ability to enhance crucial elements implicated in the development of the condition
Methods: Twenty-one male Wistar rats were divided into three groups: 1) NAFLD, 2) NAFLD + resistance training (RT), 3) NAFLD + RT + atorvastatin (ATO). The groups received high fat/fructose diet (HFFD) to induce NAFLD and it was confirmed through evaluation of histopathological analysis (H&E staining) and measurement of aminotransferase enzymes. ATO was administrated at the dose of 2 mg/kg/day. The interventions were done for eight weeks.
Results: Triglyceride (TG), Alanine transaminase (ALT), and aspartate transaminase (AST) were significantly reduced in the NAFLD + RT + ATO. Also, low-density lipoprotein (LDL) had lower level in NAFLD + RT in compared to NAFLD + RT + ATO. Alkaline phosphatase (ALP) was reduced in both NAFLD + RT and NAFLD + RT + ATO groups compared to NAFLD. There was no significant difference in weight between the groups except first, second, and forth week.
Conclusion: RT in combination with the administration of ATO can be deemed as an efficacious and supplementary strategy for the purpose of effectively controlling and addressing NAFLD.
