Showing 44 results for Ebrahim
Marzieh Niakan, Habib Alla Johari, Mehrdad Shariati, Davood Moghadamnia, Ebrahim Talebi,
Volume 17, Issue 4 (Jul-Aug 2023)
Abstract
Marzieh Niakan1 
,
Habib Alla Johari 2,
Mehrdad Shariati1 ,
Davood Moghadamnia3 ,
Ebrahim Talebi4
Background: Research has shown that the extract of some plants has an effective protective effect on liver cells against toxins and oxidants. In this research, the effect of hydroalcoholic extract of ginger against hepatotoxicity caused by doxorubicin (Dox) in adult male rats was investigated.
Methods: In this experimental study, 63 adult male rats were divided into 7 groups (n = 9 per group). The experimental treatments included the control and placebo groups without the use of medicines, experimental group I that received Dox at a dose of 20 mg/kg, experimental groups II and III with 300 and 600 mg/kg of ginger hydroalcoholic extract, and experimental groups IV and V that received 20 mg/kg Dox + 300 and 600 mg/kg of ginger hydroalcoholic extract, respectively. After the end of the test period, serum levels of total bilirubin and direct bilirubin were measured. In addition, the histological changes in the liver were examined after hematoxylin and eosin (H&E) staining.
Results: Serum levels of total bilirubin and direct bilirubin in the Dox group showed a significant increase compared to the control group. In contrast, serum levels of total bilirubin and direct bilirubin in Dox + ZIN 600 and Dox + ZIN 300 had a significant reduction compared to the Dox group (P < 0.05). Ginger extract prevented apoptosis and Dox-induced liver tissue damage in dose-dependent designs.
Conclusion: The hydroalcoholic extract of ginger improves the changes of serum bilirubin and liver tissue after receiving Dox due to its antioxidant compounds.
Hassan Esmaeili, Samaneh Shams Nateri, Mohsen Ebrahimi,
Volume 17, Issue 6 (Nov-Dec 2023)
Abstract
Background: Kawasaki disease (KD) is a febrile systemic vasculitis that affects children. Further research is required due to the disease's significance, consequences, and increasing prevalence. This study aimed to determine the frequency of coronary artery complications in patients with KD referred to Taleghani Hospital (Gorgan, Iran) from 2007 to 2017.
Methods: Between 2007 and 2017, 108 cases with a definitive diagnosis of KD were studied retrospectively. Data were obtained from medical records and the patients' biographical, clinical, laboratory, radiographic, and echocardiographic data.
Results: A total of 108 patients diagnosed with KD were involved in the study, 21 (19.44%) of whom showed coronary artery-associated complications. There was no significant difference in clinical and laboratory findings and coronary artery involvement between male and female groups (P-value < 0.05). Left coronary artery (LCA) involvement and the pattern of vascular involvement as ectasia and aneurysm were significantly higher in the echocardiography of the studied patients (P-value = 0.0001).
Conclusion: Kawasaki disease-related coronary artery complication is more common in children under the age of 3, particularly males, in Gorgan. The LCA is the most common site of coronary artery complications in KD children. The findings can improve the prognosis of KD patients and their related heart diseases.
Reyhaneh Shafieian, Alireza Ebrahimzadeh-Bideskan, Esmail Ranjbar,
Volume 18, Issue 3 (May-Jun 2024)
Abstract
Background: The purpose of tissue processing is to strengthen the tissue and place it in a suitable environment for slicing without causing damage. In routine histopathology, decalcification of calcified tissues is a principal step before tissue processing. Thus, the aim of this study is to evaluate the effect of several decalcifying agents on morphological and antigenic preservation in canine mandibular tissue.
Methods: Four different decalcifying solutions, including 5% nitric acid (NA), 10% and 20% formic acid (FA), and 10% ethylene diamine tetraacetic acid (EDTA), were employed to remove mineral salts from specimens harvested from mandibular osseous tissues of four healthy Mongrel dogs (32 samples). The solutions were compared regarding the decalcification time, ease of tissue slicing, morphological organization after Alizarin red S staining, and osteocalcin antigenic preservation.
Results: Considering the short decalcification time and ease of sectioning, 5% NA) yielded better results than 10% and 20% FA and 10% EDTA (pH 7.4). In terms of the preservation of morphology and antigenicity of the tissue samples, 10% EDTA was found to be the most optimal solution, followed by 10% and 20% FA and 5% NA.
Conclusion: Our findings support EDTA as a highly preferred choice for the decalcification of canine osseous tissue when aiming for immunohistochemistry, despite its time-consuming nature. However, for general histological staining procedures, 20% FA and 5% NA are preferred.
Ebrahim Mohammed Abed Ahamid Ahmed, Babker Ahmed Mohamed , Bakri Yousf Mohamed Nour, Babiker Saad Almugadam ,
Volume 18, Issue 4 (Jul-Aug 2024)
Abstract
Background: Acute ischemic stroke occurs when blood clots obstruct blood vessels within the brain. Platelets (Plts) are integral to the pathophysiology of stroke. This research aimed to explore the relationship between Plt quality and Plt indices in the context of acute ischemic stroke.
Methods: This cross-sectional investigation involved 100 patients diagnosed with acute ischemic stroke at Kosti Teaching Hospital and Alyammama Hospitals. The diagnosis was confirmed using brain CT imaging and electrocardiography (ECG). Blood samples were collected in EDTA-containing tubes within 24 hours following the commencement of treatment and were subsequently analyzed for Plt count, mean Plt volume (MPV), Plt distribution width (PDW), and plateletcrit (PCT) utilizing a hematological analyzer. Data were analyzed using GraphPad Prism software.
Results: Platelet counts negatively correlated with PDW [r=-0.074, P=0.459; R=-0.023, P=0.815], MPV [r=-0.130, P=0.194; R=-0.081, P=0.417], and diastolic blood pressure [r= -0.023, P=0.818; R= -0.024, P=0.805]; and positively correlated with PCT [r= 0.103, P=0.308; R=0.143, P=0.155] and diastolic blood pressure [r=0.022, P=0.823; R= 0.008, P=0.932]. Moreover, PDW positively correlated with systolic blood pressure [r=0.105, P=0.298; R= 0.147, P=0.148] and diastolic blood pressure [r=0.146, P=0.145; R=0.173, P=0.084]. Based on Spearman but not Pearson correlation, PDW showed a negative correlation with PCT [r=-0.005, P=0.959; R=0.010, P=0.929].
Conclusion: The study shows a correlation between Plt count and indices in ischemic stroke patients. The research also presented evidence concerning the relationship between diastolic and systolic blood pressure and Plt counts and indices.
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