Seyed Sadegh Baniaghil, Fardin Balochi, -- Ereste Kazak,
Volume 19, Issue 3 (7-2025)
Abstract
Background: One of the major complications in thalassemia patients is alloimmunization, which is antibody production by the patient against transfused RBCs (red blood cells). In the present study, the frequency of alloantibodies in thalassemia patients was investigated.
Materials and Methods: In this cross-sectional retrospective study, the study was performed on ninety nine multi-transfused thalassemia patients, antibody screening test was carried out using three cell-panel. Positive patients were followed up for antibody identification using 11-cell panel. The information was finally analyzed using SPSS software version 16.0.
Results: Out of ninety-nine cases, 53 were female (53.53 %) and 46 male (46.46 %). The patient’s age mean was 29.22±10.46 years with 2 to 61 years age range. Only 5.05% (N=5) had developed alloantibodies. The most common alloantibodies were Anti-D, Anti-E, Anti-c and Anti-K. No significant correlation was seen between the presence of alloantibody and age, sex, blood type and spleen condition.
Conclusion: Antibody production against RBC antigens is a common problem in multi-transfused thalassemia patients. Compatibility between antigens of Kell and Rh blood group systems in donors and recipients can be one of the useful ways to prevent alloimmunization of blood recipients and the production of unexpected antibodies against donor’s red blood cells.
