Showing 7 results for Breast Cancer
A Moradi, E Mobasheri, A Tabarraei, S Bakhshandeh Nosrat, V Kazemi Nejad, R Azarhosh, Sh Alizadeh, M Bazori,
Volume 3, Issue 1 (4-2009)
Abstract
Abstract Background and objectives: Breast cancer is the most prevalent one in women. Some of the common causative factors are genetic background, nutritional and environmental factors. Viruses are believed as a risk factor in this cancer, too. Recent studies reported that Human Papillomaviruses can be one of the possible risk factors of breast cancer. This study focused on investigation of the papillomavirus genome in tissues of breast cancer in Golestan province, Iran. Material and Methods: This descriptive analytical study was done from 2005 until 2008. The Samples were obtained from women admitted to the hospitals in Gorgan and Gonbad cities. All breast biopsy or mastectomy tissues were confirmed by the pathologists for breast cancer. DNA was extracted and PCR done by using general primers (GP5 + / GP6 + and MY09/MY11) for detection of papillomavirus genomes. Results: The Subjects are 231 patients aged 47± 12/72, the youngest 20 and the oldest 84. They are from Gorgan (N=122)and Gonbad (N=109) The result Shows That The Subjects Suffer from infiltrating ductular Carcinoma(31.4%), infiltrating duct Carcinoma (60.1%)and intraductal Lobular Carcinoma (4.3%) and The rest from other kinds of Cancer. Papilloma Virus genome is not found in These Samples. Conclusion: Based on paradoxical results from different parts of the world, upon the presence or absence of papillomavirus genome in breast cancer samples, to show the role of this virus in the development of breast cancer more studies are needed. Key words: Breast Cancer, Papillomaviruses, Golestan Province
J Asadi, N Zarghami,
Volume 8, Issue 1 (4-2014)
Abstract
Abstract
Background and Objective: Breast cancer is the most common cancer in women. Telomerase enzyme is one of the major factors causing the development and proliferation of immortal cells such as cancer cell. The aim of this study was to evaluate telomerase activity in breast tissues of breast cancer patients and healthy people.
Material and Methods: In this descriptive study, the samples from 32 patients with malignant tumors and from 24 with benign tumors or healthy individuals were obtained .To assess the relative activity of telomerase in the samples, TRAP assay (PCR-ELISA) was used.
Results: The frequency of telomerase activity was 93.75% in patients and 8% in healthy people.
Conclusion: The results indicate that the relative activity of telomerase in tumor tissues measured by TRAP assay could be a suitable biomarker for identifying the breast cancer tissue.
Keywords: TRAP Assay breast cancer telomerase
Mohammad Hassan Khadem Ansari , Khadije Meghrazi ,
Volume 11, Issue 4 (7-2017)
Abstract
ABSTRACT
Obesity is a health problem defined as abnormal or excessive fat accumulation in adipose tissue. Adipokines such as adiponectin, visfatin and resistin are bioactive polypeptides with pro- and anti-inflammatory properties that are secreted by the adipose tissue that are involved in the pathogenesis and prognosis of diseases such as type 2 diabetes, metabolic syndrome and cancer. This survey aimed to review the role of these hormones in the pathogenesis and prognosis of breast cancer in obese postmenopausal women. In obese individuals, increased level of leptin leads to tumorigenesis and progression of breast cancer though JAK/STAT3 pathway. These individuals have decreased level of adiponectin, which has a protective effect against carcinogenesis via AMPK pathway. Obese individuals also have increased level of visfatin, which induces the secretion of proinflammatory cytokines such as TNFα and triggers growth of cancer cells. Similarly, elevated resistin levels increases cell proliferation through PI3K and MAPK pathways. Obesity is associated with the dysregulated secretion of adipokines such as leptin, adiponectin, visfatin and resistin, which could be utilized for early diagnosis of breast cancer.
Keywords: Obesity, Breast Cancer, Adiponectin, Leptin, Visfatin, Resistin.
Behrouz Farhadihosseinabadi , Fahimeh Hosseini , Pegah Larki , Nader Bagheri , Kazem Abbaszadeh-Goudarzi , Koushan Sinehsepehr , Behrooz Johari , Meghdad Abdollahpour-Alitappeh ,
Volume 12, Issue 5 (9-2018)
Abstract
ABSTRACT
Breast cancer remains the most common cancer of women and one of the most common causes of cancer-related deaths worldwide. In spite of major advances in breast cancer diagnosis and treatment, the incidence of breast cancer remains high and the treatment of metastatic breast cancer remains challenging. This review presents an overview of breast cancer with a particular focus on its clinical aspects and therapies.
Keywords: Breast Cancer, Risk Factors, Diagnosis, Treatment.
Mohammad Taghi Badeleh, Robabeh Noori, Alireza Moradi ,
Volume 12, Issue 5 (9-2018)
Abstract
ABSTRACT
Background and Objectives: Cancer and its conventional treatments may bring about some psychological and health-related symptoms leading to unstable cortisol level. Since evidence has shown that mindfulness based approaches can be helpful to reduce cortisol level, we aimed at investigating the efficacy of mindfulness-based cognitive therapy (MBCT) on decreasing salivary cortisol level in the women with breast cancer.
Methods: in this one- group pretest posttest study, the women with early stage breast cancer were assessed to select eligible ones (N = 15). They were first trained for collecting salivary cortisol sample (before, after and follow-up) and then were asked to participate in MBCT, an eight-week session approach. Participants provided salivary samples in the morning (7: 30- 8:30), afternoon (1-3) and night (9-11). To measure cortisol, Cortisol Enzyme Immunoassay Kit was used. Analysis was performed on the data of 12 participants remained, using repeated measurement.
Results: the results of repeated measure ANOVA revealed that cortisol level of posttest (after 8-weeks of MBCT and follow-up period) in comparison with pretest was significantly reduced for morning and afternoon cortisol while it was not true for night cortisol. The post-treatment cortisol was not significantly correlated with age groups, education levels and socio-economic status using repeated measure ANCOVA.
Conclusion: Given that the women with breast cancer are at the high risk of psychological distresses and unstable cortisol level, we recommend mindfulness-based approaches esp. MBCT to health providers specifically those working with breast cancer patients.
Keywords: Mindfulness, MBCT, Cortisol , Salivary Cortisol, Breast cancer.
Sanaz Salar Amoli, Sima Besharat, Amir Nader Emami Razavi, Aliasghar Ayatollahi, Hamidreza Joshaghani,
Volume 13, Issue 1 (1-2019)
Abstract
Background and Objective: HER-2 (human epidermal growth factor receptor 2) is one such gene that can play a role in the development of breast cancer by making HER-2 proteins (receptorson breast cells). Normally, HER-2 receptors control breast cells grow and Division. HER-2 protein over expression is the cause of up to 20% of breast cancers. The phosphoinositide 3 kinase (PI3K) pathway is important in the oncogenic function of HER-2.
It has been reported compounds including Se, such as selenite significantly attenuated oxidative-stress-induced activation of the PI3K signaling pathways and can exhibit antitumor activity by downregulating PI3K activation.
In this study, we evaluated Association of tissue selenium level and Human epidermal growth factor receptor 2 (HER-2) expression in breast cancer.
methods:
Se contents and expression of HER-2 were determined in 30 tissue collected from 30 women diagnosed with breast cancer based on immunohistochemistry (HER-2) and atomic absorption (Se).
Results:
About 30% of the samples were positive for HER-2 expression. Mean level of tissue selenium in tumors for positive and negative HER-2 was 268.15 µg/l and 206.43µg/l respectively. So, there was no significant association between selenium level and HER-2 expression. (p>0.005)
Conclusion:
There is no Association of tissue selenium level and HER-2 expression in breast cancer.
Keyword:
Selenium, HER-2, breast cancer
Sanaz Salar Amoli , Khashayar Shahin, Sima Besharat , Amir Nader Emami Razavi , Hamidreza Joshaghani ,
Volume 13, Issue 2 (3-2019)
Abstract
ABSTRACT
Background and Objectives: Recently, the incidence of breast cancer has increased drastically worldwide. Therefore, the identification of novel diagnostic biomarkers is essential for improving treatment outcomes and prognosis. Estrogen receptor (ER) and progesterone receptor (PR) are routinely available in breast cancer specimens. Semi-quantitative assessment of ER and PR is important for prognosis. Even with the development of genomic tests, hormone receptor status remains the most significant predictive and prognostic biomarker. Selenium is known to protect mammary epithelial cells against oxidative DNA damage and early carcinogenetic events. Since overexpression of ER and PR is common in breast cancers, we aimed to evaluate association of tissue selenium level and ER and PR expression in breast cancer.
Methods: Sixty tissue samples (30 tumors and 30 tumor margins) were collected from patients with breast cancer. Selenium level was measured using graphite furnace atomic absorption spectroscopy and ER/PR expression was evaluated using immunohistochemistry.
Results: About 60% of the samples were positive for ER/PR expression. Mean level of tissue selenium was 209.54 µg/L in tumors and 185.04 µg/L in tumor margins that were ER/PR positive. In addition, mean selenium level was 243.39 µg/L and 168.06 µg/L in ER/PR-negative tumors and tumor margins, respectively. There was no significant association between selenium level and ER/PR expression (P>0.05).
Conclusion: There is no association between tissue Se level and ER/PR expression in breast cancer.
Keywords: Selenium, Estrogen receptor (ER), progesterone receptor (PR), breast cancer.
