Showing 2 results for Catalase
E Kharazi-Nejad, A Nakhaee, M Taheri,
Volume 7, Issue 4 (1-2014)
Abstract
Abstract
Background and Objective: One of the diabetes complications is the tissue damage caused by the imbalance of oxidants and antioxidants (oxidative stress). The aim of the present study was to evaluate the activity of two antioxidant enzymes -superoxide dismutase and catalase- in the serum of streptozotocin-induced diabetic rats.
Material and Methods: This investigation was conducted on adult male rats assigned to diabetic and control groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Seven weeks after diabetes induction, glucose concentration, superoxide dismutase and catalase activities of the serum were assessed.
Results: Glucose concentration of streptozotocin-injected animals was significantly higher than that of control group (P<0.001). The level of Serum superoxide dismutase and catalase activities in diabetes group were significantly higher than those in control group (P<0.01). There was a positive significant correlation between glucose concentration and superoxide dismutase and catalase activities (P<0.001).
Conclusion: The high activity of antioxidant enzymes in diabetic rats is probably due to compensation responses to oxidative stress produced by high concentration of free radicals. It seems that the higher glucose concentration, the greater compensatory responses.
Keywords: Diabetes, Streptozotocin, Antioxidant, Superoxide Dismutase, Catalase
A Sharifi, N Razmi, N Naghsh,
Volume 7, Issue 4 (1-2014)
Abstract
Abstract
Background and Objective: Flavonoids play an important role in non-enzymatic reaction against oxidative stress. These are polyphenolic compounds in tea structure that could be reacted with free radicals and neutralized them. In this study, we investigated the anti-oxidant impact of Camellia Sinesis on the liver of thioacetamide -injected male albino mice.
Material and Methods: In this study, 40 male mice were categorized in five groups of eight. The first group was control. The second and the third group received 100mg/kg and 150mg/kg of thioacetamide, respectively. The fourth group received 100mg/kg thioacetamide followed by black tea (5 gr/100) and the fifth one received 150mg/kg thioacetamide followed by black tea (5 gr/100). Tioacetamide was given via intraperitoneal. After that, for 30 days, they were only fed on black tea (5 gr/100). At the end, catalase (CAT) and glutathione peroxidase (GPx) activity were measured.
Results: Based on the results, catalase(CAT) and glutathione peroxidase(GPx) activity were significantly increased in the groups of Thioacetamide and black tea compared to those of only Thioacetamide groups (p<0.05).
Conclusion: The increase of these enzymes in tea groups shows the anti-oxidant effect of black tea that can be caused by Catechin.
Keywords: Antioxidant Thioacetamide Black Tea Glutathione Peroxidase Catalase
