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Frequency of H.Pylory BabA2 and Hpa Genes in Patients with Dysphagia
Khatoon Heydari, Ramin Azarhoosh, Vahideh Kazeminejhad, Fatemeh Shakeri, Alireza Noroozi,
Volume 9, Issue 5 (11-2015)
Abstract

Abstract

      Background and Objective: BabA2 and Hpa genes are involved in adherence of Helicobacter pylori (H.pylori) to gastric mucosal tissue. This study aimed to investigate the frequency of these genes in isolates of H. pylori from gastric biopsies and their relationship with gastritis, peptic ulcer and gastric cancer.

      Methods: Gastric biopsy samples were obtained from patients with gastritis, peptic ulcer and gastric cancer. A sample was sent to the laboratory for urease test and histopathology study, and another sample for DNA extraction. The frequency of BabA2 and Hpa genes was investigated using their specific primers by PCR.

      Results: Among the 80 analyzed biopsy samples, 51 (63%) were BabA2 positive, and the frequency of this gene in the samples of gastric cancer, gastritis and peptic ulcer was 61.1, 58.3 and 73.3%, respectively. In addition, 57 samples (71%) were Hpa positive, and the frequency of this gene in the samples of gastric cancer, gastritis and peptic ulcer was 55.5, 69.4 and 84.6%, respectively. There was no significant correlation between the presence of these genes and the type of H.pylori-related diseases.

       Conclusion: Frequency of BabA2 and Hpa genes is higher in the samples of peptic ulcer but there was no significant relationship between these genes and H.pylori-related diseases.

      Keywords: BabA2, Hpa, Gastric Cancer, Gastritis, Peptic Ulcer.


Expression Changes in the Fibulin Family in Gastric Cancer: A Systematic Review
Mahsa Mahdizadeh, Zeinab Mohammadi, Seyyed Mehdi Jafari,
Volume 19, Issue 2 (3-2025)
Abstract
Background: Gastric cancer (GC) is one of the widespread gastrointestinal tumors in the worldwide, with mortality rates among the highest. In the world, we face more than one million newly diagnosed stomach cancer patients every year. Various factors closely associated with formation of GC. One of these factors is the change in the level of components of the extracellular matrix in the microenvironment of the stomach tumor. Fibulins are one of the secreted glycoproteins of extracellular matrix, which are known as matrix organizers. The purpose of this study is to investigate the changes in fibulins in gastric tumor tissue compared to control samples.
Methods: Scopus, PubMed, and Web of Science databases were searched for articles that examined FBLN gene family and protein expression in patients with gastric cancer and gastric cancer cell lines.
Results: A total of 853 gastric cancer tumor samples, ranging from 8 to 197 per study, were analyzed across eight studies published between 2008 and 2023, all conducted in China. Several gastric cancer cell lines were also included, such as AGS, Kato III, MKN28, MKN45, SNU1, SNU16, NCI-N87, MGC-803, BGC-823, SGC-7901, and HGC27. Tumor size was reported in 4 studies, while histopathological grade and lymph node metastasis were each evaluated in 4 studies.
Conclusion: The downregulation of Fibulin-1 and Fibulin-2 supports their potential tumor-suppressive roles in gastric cancer, while the upregulation of Fibulin-5 is associated to tumor progression and worse prognosis, making it a candidate biomarker for aggressive disease.
 
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