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Ali Reza Barari ,
Volume 10, Issue 4 (7-2016)
Abstract

ABSTRACT

        Background and Objective: Exercise training and supplementation have different effects on the immune system. The aim of the present study was to evaluate the effect of ginger supplementation and endurance training on serum levels of Interleukin 1 alpha (IL1α) and tumour necrosis factor α (TNFα) in untrained young women.

        Methods: The study was performed on 32 untrained young women with mean age of 30±2 years from city of Abbas Abad, in 2014. The participants were randomly assigned into four groups of endurance training (E), endurance training and ginger supplementation (EG), ginger supplementation (G) and control (C). Endurance training was performed at 60-70% heart rate reserve for six weeks, three times a week, and for 60 minutes per session. Daily supplementation with 10 mg/Kg/day of ginger extract was carried out. T-test and ANOVA were used to evaluate the effect of independent variables, and make comparisons between the groups.

          Results: The mean level of IL-1α decreased significantly after the training period in the G and EG groups. There were significant differences between E and EG groups and EG and C groups. The results of intergroup comparison showed that the mean levels of TNFα decreased significantly after the training in the E, G and EG groups. There were significant differences between E and EG groups, E and G groups, EG and C groups, and G and C groups.

         Conclusion: Ginger consumption and adaptation to endurance training can counteract the negative effects on immune function and stability of mast cell membrane.

          Keywords: Endurance Training, Ginger, IL-1alpha and TNF-alpha.


Seyed Mahmud Hejazi, Ladan Hosseni Abrishami,
Volume 14, Issue 5 (9-2020)
Abstract

Background and objectives: Evidence has shown that inflammatory mediators play an important role in the pathogenesis of atherosclerosis. The aim of this study was to evaluate effects of eight weeks of continuous and intermittent aerobic exercise on some inflammatory indices in men with heart failure.
Methods: The effects of continuous aerobic exercise (at 45-70% maximum heart rate) and intermittent aerobic exercise (at 45-80% of maximum heart rate) on the level of interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor alpha (TNFα) were evaluated in 42 men with heart failure using commercial ELISA kits. Blood samples were taken after 12 hours of fasting one hour before the first session and 48 hours after the last exercise session. The subjects performed exercises three sessions a week, for eight weeks. Data were analyzed by one-way ANOVA at significance of 0.05.
Results: After the exercise program, serum hs-CRP (P=0.023), IL-6 (P=0.018) and TNF-α (P=0.048) differed significantly between the exercise groups and the control group. In addition, serum levels of IL-6 and hs-CRP decreased slightly in the intermittent aerobic group, but there was no significant difference between the two exercise groups. Intermittent aerobic exercise significantly reduced serum TNF-α level compared to the control group.
Conclusion: Probably aerobic exercise can have positive effects on the level of hs-CRP, IL-6 and TNF-α in patients with heart failure.

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