Taiebeh Tamoradi, Hamid Goudarziafshar , Somayeh Rashki , Fatemeh Katouzian, Firoozeh Chalabian,
Volume 11, Issue 2 (3-2017)
Abstract
ABSTRACT
Background and objectives: Synthesis and characterization of several metal complexes (metal ions: Co2+, Ti4+ and Ce3+) of macroacyclic Schiff base ligand have been reported. The Schiff base ligand is prepared from the condensation reaction of 1, 4-di-(4-fluoro-2-aminophenoxy) butane with salicylaldehyde in ethanol. In addition, antibacterial activity of metal ions, Schiff base ligand and their complexes have been investigated. Recent studies show that many Schiff base complexes have antibacterial activity against Gram-positive and Gram-negative bacteria. Therefore, we aimed to synthesize new Schiff base complexes and evaluate their antibacterial activity against a number of Gram-positive and Gram-negative bacteria.
Methods: Schiff base ligand and their complexes were characterized by mass spectrometry and IR, H-NMR and C-NMR spectroscopy. The in vitro antibacterial activity of the Schiff base ligand, metal ions and their complexes were evaluated against some Gram-positive and Gram-negative bacteria by disk diffusion method and determining minimum inhibitory concentration.
Results: In this study, the Schiff base complexes had good antibacterial activity, but the Schiff base ligand and metal ions did not show any antibacterial effect. In some cases, the antibacterial effect of the complexes was higher than that of the standard antibiotics tetracycline and gentamycin. The titanium complex showed the highest antibacterial activity in both methods. This complex created the largest growth inhibition zone (diameter: 100mm) against Staphylococcus aureus, and had the lowest minimum inhibitory concentration against Bacillus subtilis (6.75 mg/ml).
Conclusion: The compounds synthesized in our study have strong antibacterial activity.
Keywords: Schiff base complex, Schiff base ligand, antibacterial activity, Staphylococcus aureus, Bacillus subtilis.
Dr Mojtaba Raeisi, Dr Fatemeh Hooshmand, Dr Marziyeh Gheraati, Dr Masood Aman Mohammadi, Dr Negin Mehdinejad,
Volume 19, Issue 3 (7-2025)
Abstract
Background and Objectives:
The rise of antibiotic-resistant bacterial strains and increasing consumer demand for natural food preservatives have driven research into plant-based antimicrobial agents. Salix aegyptiaca L. (Musk Willow) has shown potential as a source of bioactive compounds, but its antibacterial properties remain underexplored. This study aims to investigate the chemical composition and antibacterial efficacy of essential oils extracted from the leaves and male inflorescence of S. aegyptiaca against key foodborne pathogens, including Staphylococcus aureus, Escherichia coli, Listeria monocytogenes, and Salmonella enteritidis.
Methods:
Essential oils were extracted from S. aegyptiaca leaves and male inflorescence using hydrodistillation and analyzed through Gas Chromatography-Mass Spectrometry (GC-MS) to identify bioactive compounds. Antibacterial activity was evaluated using Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and diffusion methods (Agar Disk and Agar Well Diffusion).
Results:
GC-MS analysis revealed high concentrations of 1,4-Dimethoxybenzene, Citronellol, and Eugenol in leaf oil and Carvone in male inflorescence oil. The leaf oil exhibited stronger antimicrobial effects, with MIC values as low as 1250 µg/mL against S. aureus. Both oils showed limited efficacy against Gram-negative. S. aureus was the most susceptible strain, while E. coli displayed the highest resistance.
Conclusion:
The essential oils of S. aegyptiaca, particularly from the leaves, demonstrate notable antibacterial activity against common foodborne pathogens. These findings suggest their potential as natural food preservatives, offering an alternative to synthetic additives. Further research into their application in food systems and toxicological profiles is warranted to fully harness their benefits.
